2022 Sydney Tennis Classic – Men's singles

Aslan Karatsev defeated Andy Murray in the final, 6–3, 6–3 to win the men's singles title at the 2022 Sydney Tennis Classic. This was Murray's first ATP final since he won the 2019 European Open.

Alex de Minaur was the defending champion from when the event was held in 2019, but withdrew before the tournament began.

Seeds
The top four seeds receive a bye into the second round. • #🇷🇺 Aslan Karatsev (champion)

• # Nikoloz Basilashvili (second round)

• #🇬🇧 Dan Evans (semifinals)

• #🇺🇸 Reilly Opelka (semifinals)

• #🇮🇹 Lorenzo Sonego (quarterfinals)

• #🇷🇸 Dušan Lajović (second round)

• #🇮🇹 Fabio Fognini (second round)

• #🇧🇪 David Goffin (quarterfinals, retired)

Seeds
• # 🇦🇷 Facundo Bagnis (moved to main draw)

• # 🇮🇹 Stefano Travaglia (qualifying competition, lucky loser)

• # 🇨🇿 Jiří Veselý (qualified)

• # 🇩🇪 Daniel Altmaier (qualifying competition, lucky loser)

• # 🇪🇸 Pablo Andújar (first round)

• # 🇦🇷 Sebastián Báez (qualified)

• # 🇮🇹 Andreas Seppi (first round)

• # 🇺🇸 Denis Kudla (qualifying competition, lucky loser)

Qualifiers
• # 🇳🇴 Viktor Durasovic

• # 🇦🇺 Christopher O'Connell

• # 🇨🇿 Jiří Veselý

• # 🇦🇷 Sebastián Báez

Lucky losers
• # 🇮🇹 Stefano Travaglia

• # 🇩🇪 Daniel Altmaier

• # 🇺🇸 Denis Kudla