2022 Tallahassee Tennis Challenger – Singles

Jenson Brooksby was the defending champion but chose not to defend his title.

Wu Tung-lin won the title after defeating Michael Mmoh 6–3, 6–4 in the final.

Seeds
• # 🇦🇷 Tomás Martín Etcheverry (second round)

• # 🇺🇸 Steve Johnson (first round)

• # 🇨🇴 Daniel Elahi Galán (semifinals)

• # 🇪🇨 Emilio Gómez (second round)

• # Tomás Barrios Vera (second round)

• # 🇺🇸 J. J. Wolf (quarterfinals)

• # 🇺🇸 Mitchell Krueger (second round, retired)

• # 🇺🇸 Tennys Sandgren (first round)