2022 Tennis Napoli Cup

The 2022 Tennis Napoli Cup was a professional men's tennis tournament played on outdoor hard courts. It was the 21st edition of the tournament, and part of the ATP Tour 250 series of the 2022 ATP Tour. It took place at the Tennis Club Napoli in Naples, Italy from 17 to 23 October 2022.

The tournament was upgraded from an ATP Challenger Tour event to an ATP Tour 250 event this year. It was one of the six tournaments that were given single-year ATP 250 licenses in September and October 2022 due to the cancellation of tournaments in China because of the ongoing COVID-19 pandemic.

Singles

 * 🇮🇹 Lorenzo Musetti def. 🇮🇹 Matteo Berrettini, 7–6(7–5), 6–2

Doubles

 * Ivan Dodig / 🇺🇸 Austin Krajicek def. 🇦🇺 Matthew Ebden / 🇦🇺 John Peers, 6–3, 1–6, [10–8]

Seeds

 * Rankings are as of 10 October 2022

Other entrants
The following players received wildcards into the singles main draw:
 * 🇮🇹 Matteo Berrettini
 * 🇮🇹 Flavio Cobolli
 * 🇮🇹 Luca Nardi

The following players received entry from the qualifying draw:
 * Borna Gojo
 * Nicolás Jarry
 * 🇮🇹 Francesco Passaro
 * 🇨🇳 Zhang Zhizhen

Withdrawals

 * Before the tournament
 * 🇪🇸 Alejandro Davidovich Fokina → replaced by 🇪🇸 Bernabé Zapata Miralles
 * 🇫🇷 Gaël Monfils → replaced by Nuno Borges
 * 🇺🇸 Brandon Nakashima → replaced by 🇫🇷 Hugo Grenier
 * Andrey Rublev → replaced by 🇯🇵 Taro Daniel

Seeds

 * Rankings are as of 10 October 2022

Other entrants
The following pairs received wildcards into the doubles main draw:
 * 🇮🇹 Francesco Maestrelli / 🇮🇹 Francesco Passaro
 * 🇮🇹 Stefano Napolitano / 🇮🇹 Andrea Pellegrino