2022 Tennis Napoli Cup – Singles

Lorenzo Musetti defeated Matteo Berrettini in the final, 7–6(7–5), 6–2 to win the singles tennis title at the 2022 Napoli Cup. It was his second career ATP Tour singles title.

Tallon Griekspoor was the reigning champion from 2021, when the tournament was an ATP Challenger Tour event, but chose to compete in Antwerp instead.

Seeds
The top four seeds received a bye into the second round. • #🇪🇸 Pablo Carreño Busta (quarterfinals)

• #🇮🇹 Matteo Berrettini (final)

• #🇪🇸 Roberto Bautista Agut (second round)

• #🇮🇹 Lorenzo Musetti (champion)

• #🇷🇸 Miomir Kecmanović (semifinals)

• #🇦🇷 Sebastián Báez (second round)

• #🇪🇸 Albert Ramos Viñolas (first round)

• #🇫🇷 Adrian Mannarino (first round)

Seeds
• # Nicolás Jarry (qualified)

• # 🇨🇳 Zhang Zhizhen (qualified)

• # 🇮🇹 Francesco Passaro (qualified)

• # 🇸🇰 Jozef Kovalík (first round, retired)

• # 🇦🇹 Filip Misolic (qualifying competition)

• # 🇮🇹 Andrea Pellegrino (first round)

• # 🇮🇹 Giulio Zeppieri (qualifying competition)

• # 🇮🇹 Raúl Brancaccio (qualifying competition)

Qualifiers
• # Nicolás Jarry

• # 🇨🇳 Zhang Zhizhen

• # 🇮🇹 Francesco Passaro

• # Borna Gojo