2022 Texas A&M–Commerce Lions football team

The 2022 Texas A&M–Commerce Lions football team represented Texas A&M University–Commerce as a member of the Southland Conference during the 2022 NCAA Division I FCS football season. They were led by head coach David Bailiff, who coached his third and final season with the program. The Lions played their home games at Memorial Stadium in Commerce, Texas.

This was the programs inaugural season in the Southland Conference.

Preseason poll
The Southland Conference released their preseason poll on July 20, 2022. The Lions were picked to finish sixth in the conference.

Schedule
Texas A&M–Commerce finalized their 2022 schedule on January 20, 2022.