2022 The Women's Hospital Classic – Singles

Rebecca Marino was the defending champion but chose not to participate.

Ashlyn Krueger won the title, defeating Sachia Vickery in the final, 6–3, 7–5.

Seeds
• # 🇺🇸 Alycia Parks (first round)

• # 🇺🇸 Robin Anderson (first round)

• # 🇺🇸 Caroline Dolehide (first round)

• # 🇨🇦 Carol Zhao (quarterfinals)

• # 🇺🇸 Sachia Vickery (final)

• # 🇺🇸 Emina Bektas (first round)

• # 🇺🇸 Kayla Day (second round, withdrew)

• # 🇲🇽 Marcela Zacarías (second round)