2022 U.S. Men's Clay Court Championships

The 2022 U.S. Men's Clay Court Championships (also known as the Fayez Sarofim & Co. U.S. Men's Clay Court Championships for sponsorship purposes) was a tennis tournament played on outdoor clay courts.

It was the 52nd edition of the U.S. Men's Clay Court Championships, and an ATP Tour 250 event on the 2022 ATP Tour. It was originally scheduled to take place at River Oaks Country Club in Houston, Texas, United States for April 6 through April 12, 2020, but this edition of the tournament was postponed to April 4 through April 10, 2022 due to the COVID-19 pandemic.

Singles

 * 🇺🇸 Reilly Opelka def. 🇺🇸 John Isner, 6–3, 7–6(9–7)

Doubles

 * 🇦🇺 Matthew Ebden / 🇦🇺 Max Purcell def. 🇷🇸 Ivan Sabanov / 🇷🇸 Matej Sabanov, 6–3, 6–3

Prize money

 * per team

Seeds

 * Rankings are as of March 21, 2022.

Other entrants
The following players received wildcards into the main draw:
 * 🇦🇺 Nick Kyrgios
 * 🇺🇸 Jack Sock
 * 🇺🇸 J. J. Wolf

The following players received entry via the qualifying draw:
 * Gijs Brouwer
 * 🇺🇸 Christian Harrison
 * 🇺🇸 Mitchell Krueger
 * 🇦🇺 Max Purcell

The following players received entry as a lucky loser:
 * 🇨🇦 Steven Diez
 * 🇺🇸 Michael Mmoh

Withdrawals

 * Before the tournament
 * Kevin Anderson → replaced by 🇨🇴 Daniel Elahi Galán
 * 🇦🇷 Francisco Cerúndolo → replaced by 🇵🇪 Juan Pablo Varillas
 * Lloyd Harris → replaced by 🇺🇸 Sam Querrey
 * 🇫🇷 Adrian Mannarino → replaced by 🇺🇸 Steve Johnson
 * 🇪🇸 Jaume Munar → replaced by 🇨🇦 Steven Diez
 * 🇳🇴 Casper Ruud → replaced by 🇺🇸 Michael Mmoh
 * 🇰🇷 Kwon Soon-woo → replaced by 🇺🇸 Denis Kudla

Seeds

 * 1 Rankings as of March 21, 2022.

Other entrants
The following pairs received a wildcard into the doubles main draw:
 * 🇺🇸 William Blumberg / 🇺🇸 Max Schnur
 * 🇦🇺 Nick Kyrgios / 🇺🇸 Jack Sock

Withdrawals

 * Before the tournament
 * 🇺🇸 Nicholas Monroe / 🇺🇸 Frances Tiafoe → replaced by 🇺🇸 Nicholas Monroe / 🇧🇷 Fernando Romboli
 * 🇺🇸 Marcos Giron / 🇺🇸 Hunter Reese → replaced by Pablo Cuevas / 🇺🇸 Hunter Reese