2022 U.S. Pro Women's Clay Court Championships

The 2022 U.S. Pro Women's Clay Court Championships was a professional tennis tournament played on outdoor clay courts. It was the seventh edition of the tournament which was part of the 2022 ITF Women's World Tennis Tour. It took place in Palm Harbor, Florida, United States between 11 and 17 April 2022.

Seeds

 * 1 Rankings are as of 4 April 2022.

Other entrants
The following players received wildcards into the singles main draw:
 * 🇺🇸 Hailey Baptiste
 * 🇺🇸 Sophie Chang
 * 🇺🇸 Peyton Stearns
 * 🇺🇸 Taylor Townsend

The following players received entry from the qualifying draw:
 * 🇺🇸 Hanna Chang
 * 🇫🇷 Salma Djoubri
 * 🇺🇸 Elvina Kalieva
 * 🇷🇴 Gabriela Lee
 * 🇺🇸 Maegan Manasse
 * 🇦🇺 Seone Mendez
 * 🇺🇸 Whitney Osuigwe
 * 🇲🇽 María José Portillo Ramírez

The following player received entry as a lucky loser:
 * 🇺🇸 Catherine Harrison

Singles

 * 🇺🇸 Katie Volynets def. 🇨🇳 Wang Xiyu 6–4, 6–3

Doubles

 * 🇺🇸 Sophie Chang / 🇺🇸 Angela Kulikov def. 🇷🇴 Irina Bara / 🇮🇹 Lucrezia Stefanini 6–4, 3–6, [10–8]