2022 US Open – Boys' singles

Daniel Rincón was the reigning champion, but is no longer eligible to participate in junior events.

Martín Landaluce won the title, defeating Gilles-Arnaud Bailly in the final, 7–6(7–3), 5–7, 6–2.

Seeds
• Daniel Vallejo (semifinals)

• 🇧🇪 Gilles-Arnaud Bailly (final)

• Kilian Feldbausch (quarterfinals)

• 🇺🇸 Nishesh Basavareddy (second round)

• 🇪🇸 Martín Landaluce (champion)

• 🇦🇷 Lautaro Midón (second round)

• 🇵🇪 Gonzalo Bueno (third round)

• 🇱🇹 Edas Butvilas (second round)

• 🇭🇰 Coleman Wong (semifinals)

• 🇵🇱 Martyn Pawelski (second round)

• 🇨🇿 Jakub Nicod (second round)

• 🇵🇪 Ignacio Buse (first round)

• 🇰🇷 Gerard Campana Lee (third round)

•  Yaroslav Demin (third round)

• 🇨🇦 Jaden Weekes (first round)

• 🇺🇸 Michael Zheng (third round)

Seeds
• # Danil Panarin (qualifying competition)

• # 🇰🇿 Max Batyutenko (first round)

• # 🇺🇸 Yannik Rahman (qualifying competition)

• # 🇵🇱 Borys Zgoła (qualified)

• # 🇨🇾 Constantinos Koshis (qualified)

• # 🇬🇧 William Jansen (qualified)

• # 🇯🇵 Lennon Roark Jones (first round)

• # 🇲🇽 Luis Carlos Álvarez Valdés (first round)

• # 🇹🇷 Togan Tokaç (qualified)

• # 🇯🇵 Kenta Miyoshi (first round)

• # Ivan Šodan (first round)

• # 🇸🇪 Sebastian Eriksson (first round)

• # 🇦🇺 Edward Winter (qualified)

• # 🇬🇧 Patrick Brady (qualified)

• # 🇺🇸 Meecah Bigun (qualifying competition)

• # Tiago Pereira (first round)

Qualifiers
• # 🇹🇷 Togan Tokaç

• # 🇺🇸 Sean Daryabeigi

• # 🇬🇧 Patrick Brady

• # 🇵🇱 Borys Zgoła

• # 🇨🇾 Constantinos Koshis

• # 🇬🇧 William Jansen

• # 🇺🇸 Hudson Rivera

• # 🇦🇺 Edward Winter

Lucky loser

 * 1) 🇺🇸 Calvin Baierl