2022 US Open – Girls' singles

Robin Montgomery was the reigning champion, but chose not to participate.

Alex Eala won the title, defeating Lucie Havlíčková in the final, 6–2, 6–4. Eala became the first Philippine player to win the girls' title in the major, and the first player from Southeast Asia since Angelique Widjaja at the 2002 French Open. Eala also became the first player to win the title without losing a set throughout the tournament since Amanda Anisimova at the 2017 US Open.

Seeds
• 🇧🇪 Sofia Costoulas (third round)

• 🇨🇿 Lucie Havlíčková (final)

• 🇺🇸 Liv Hovde (second round)

• Céline Naef (quarterfinals)

• 🇦🇷 Solana Sierra (second round)

• 🇸🇰 Nikola Daubnerová (first round)

•  Diana Shnaider (semifinals)

• 🇦🇺 Taylah Preston (third round)

• 🇨🇦 Victoria Mboko (semifinals)

•  Alex Eala (champion)

• 🇭🇺 Luca Udvardy (second round)

• 🇯🇵 Sara Saito (first round)

•  Johanne Svendsen (second round)

•  Mirra Andreeva (quarterfinals)

•  Ksenia Zaytseva (first round)

• 🇺🇸 Qavia Lopez (first round)

Seeds
• # 🇰🇿 Aruzhan Sagandikova (qualified)

• # Li Yu-yun (first round)

• # 🇹🇷 Melisa Ercan (qualified)

• # 🇰🇿 Sandugash Kenzhibayeva (qualifying competition)

• # 🇲🇦 Malak El Allami (first round)

• # 🇹🇷 Ayşegül Mert (qualifying competition)

• # 🇺🇸 Ava Krug (first round)

• # 🇸🇰 Renáta Jamrichová (qualified)

• # 🇵🇱 Olivia Lincer (qualifying competition)

• # 🇺🇸 Ahmani Guichard (qualifying competition)

• # 🇵🇱 Weronika Ewald (qualified)

• # 🇺🇸 Theadora Rabman (first round)

• # 🇨🇿 Amélie Šmejkalová (first round)

• # Ela Nala Milić (first round)

• # Chelsea Fontenel (first round)

• # 🇵🇱 Ada Piestrzyńska (first round)

Qualifiers
• # 🇰🇿 Aruzhan Sagandikova

• # 🇺🇸 Alanis Hamilton

• # 🇹🇷 Melisa Ercan

• # 🇵🇱 Weronika Ewald

• # 🇺🇸 Katherine Hui

• # 🇺🇸 Tatum Evans

• # Rebecca Munk Mortensen

• # 🇸🇰 Renáta Jamrichová