2022 US Open – Wheelchair men's doubles

Martín de la Puente and Nicolas Peifer defeated the five-time defending champions Alfie Hewett and Gordon Reid in the final, 4–6, 7–5, [10–6] to win the men's doubles wheelchair tennis title at the 2022 US Open. It was de la Puente's maiden major title, and Peifer's eighth in doubles.

Seeds
• # 🇬🇧 Alfie Hewett / 🇬🇧 Gordon Reid (final)

• # 🇪🇸 Martín de la Puente / 🇫🇷 Nicolas Peifer (champions)