2022 US Open – Wheelchair men's singles

Alfie Hewett defeated the two-time defending champion Shingo Kunieda in the final, 7–6(7–2), 6–1 to win the men's singles wheelchair tennis title at the 2022 US Open. It was his third US Open singles title and sixth major singles title overall. Kunieda was attempting to complete the first Grand Slam in wheelchair men's singles history.

Seeds
• #🇯🇵 Shingo Kunieda (final)

• #🇬🇧 Alfie Hewett (champion)

• #🇦🇷 Gustavo Fernández (first round)

• #🇯🇵 Tokito Oda (quarterfinals)