2022 US Open – Wheelchair quad singles

Niels Vink defeated Sam Schröder in the final, 7–5, 6–3 to win the quad singles wheelchair tennis title at the 2022 US Open. It was his first US Open singles title and second major singles title overall.

Dylan Alcott was the reigning champion, but retired from professional wheelchair tennis in January 2022.

Seeds
• # Niels Vink (champion)

• # Sam Schröder (final)