2022 US Open – Women's singles

Iga Świątek defeated Ons Jabeur in the final, 6–2, 7–6(7–5) to win the women's singles tennis title at the 2022 US Open. It was her first US Open title, third major title overall and second of the season, making Świątek the first player since Angelique Kerber in 2016 to win multiple majors in a season. Świątek became the first Polish woman in the Open Era to reach the US Open quarterfinals and beyond. Świątek also became the youngest woman to win three majors since Maria Sharapova in 2008.

Emma Raducanu was the defending champion, but lost in the first round to Alizé Cornet. It was the third time the defending US Open champion lost in the first round, after Svetlana Kuznetsova in 2005 and Kerber in 2017. This marked the second consecutive major where Cornet defeated a reigning major champion (following her victory over reigning French Open champion and world No. 1 Świątek at Wimbledon). Cornet made her 63rd consecutive major appearance, surpassing the all-time record she had jointly held with Ai Sugiyama.

This tournament marked the final professional appearance for 23-time singles major champion, Olympic singles gold medalist, and former world No. 1 Serena Williams; she lost to Ajla Tomljanović in the third round. It was the longest match at a major tournament in her career, lasting three hours and five minutes. With her victory over second-ranked Anett Kontaveit in the second round, Williams became the oldest player to defeat a top-three player on the WTA Tour.

This tournament marked the first time in the Open Era that four Chinese women reached the third round. Elena Rybakina lost in the first round to Clara Burel; that marked the first time that the reigning Wimbledon champion had lost in the first round of the US Open since Petra Kvitová in 2011. Elise Mertens had her streak of 18 consecutive major third-rounds broken after losing in the first round to Irina-Camelia Begu.

This was the first edition of the US Open to feature a 10-point tie-break, when the score reaches six games all in the deciding set. Karolína Plíšková defeated Magda Linette in the first round in the first women's singles main-draw 10-point tie-break at the US Open.

Seeds
• 🇵🇱 Iga Świątek (champion)

• 🇪🇪 Anett Kontaveit (second round)

• Maria Sakkari (second round)

• 🇪🇸 Paula Badosa (second round)

• 🇹🇳 Ons Jabeur (final)

•  Aryna Sabalenka (semifinals)

• 🇷🇴 Simona Halep (first round)

• 🇺🇸 Jessica Pegula (quarterfinals)

• 🇪🇸 Garbiñe Muguruza (third round)

•  Daria Kasatkina (first round)

• 🇬🇧 Emma Raducanu (first round)

• 🇺🇸 Coco Gauff (quarterfinals)

•  Belinda Bencic (third round)

• 🇨🇦 Leylah Fernandez (second round)

• 🇧🇷 Beatriz Haddad Maia (second round)

•  Jeļena Ostapenko (first round)

• 🇫🇷 Caroline Garcia (semifinals)

•  Veronika Kudermetova (fourth round)

• 🇺🇸 Danielle Collins (fourth round)

• 🇺🇸 Madison Keys (third round)

• 🇨🇿 Petra Kvitová (fourth round)

• 🇨🇿 Karolína Plíšková (quarterfinals)

• 🇨🇿 Barbora Krejčíková (second round)

• 🇺🇸 Amanda Anisimova (first round)

• 🇰🇿 Elena Rybakina (first round)

•  Victoria Azarenka (fourth round)

• 🇮🇹 Martina Trevisan (first round)

•  Ekaterina Alexandrova (second round)

• 🇺🇸 Alison Riske-Amritraj (fourth round)

•  Jil Teichmann (first round)

• 🇺🇸 Shelby Rogers (third round)

• 🇧🇪 Elise Mertens (first round)

Seeded players
The following are the seeded players. Seedings are based on WTA rankings as of August 22, 2022. Rankings and points are as before August 29, 2022.

† The player did not qualify for the tournament in 2021 and is defending points from two ITF tournaments (Collonge-Bellerive and Montreux) instead.

‡ The player was not required to include zero points for the 2021 tournament in her ranking due to the WTA's COVID-19 rules. Accordingly, points for her 16th best result will be deducted instead.

Wild cards
• 🇦🇺 Jaimee Fourlis

• 🇺🇸 Sofia Kenin

• 🇺🇸 Elizabeth Mandlik

• 🇺🇸 Peyton Stearns

• 🇫🇷 Harmony Tan

• 🇺🇸 CoCo Vandeweghe

• 🇺🇸 Venus Williams

• 🇺🇸 Eleana Yu Source:

Protected ranking
• 🇺🇸 Serena Williams (16)

• 🇨🇿 Karolína Muchová (22)

• 🇦🇷 Nadia Podoroska (39)

• 🇩🇪 Laura Siegemund (57)

• Evgeniya Rodina (73)

• 🇺🇸 Taylor Townsend (84)

Qualifiers
• Erika Andreeva

•  Elina Avanesyan

• 🇨🇿 Sára Bejlek

• 🇪🇸 Cristina Bucșa

• 🇫🇷 Clara Burel

• 🇮🇹 Elisabetta Cocciaretto

• 🇲🇽 Fernanda Contreras Gómez

• 🇨🇿 Linda Fruhvirtová

•  Viktorija Golubic

• 🇺🇸 Catherine Harrison

• 🇫🇷 Léolia Jeanjean

• 🇺🇸 Ashlyn Krueger

• 🇸🇰 Viktória Kužmová

• 🇨🇿 Linda Nosková

• 🇺🇦 Daria Snigur

• 🇨🇳 Yuan Yue

Lucky losers
• Kamilla Rakhimova

Withdrawals
The entry list was released by the United States Tennis Association based on the WTA rankings for the week of July 18. • † 🇺🇦 Elina Svitolina (42) → replaced by 🇧🇪 Greet Minnen (99)

• & Anastasia Pavlyuchenkova (97) → replaced by 🇩🇪 Tatjana Maria (100)

• & 🇨🇿 Markéta Vondroušová (49) → replaced by 🇨🇦 Rebecca Marino (101)

• & 🇸🇰 Kristína Kučová (90) → replaced by 🇩🇪 Jule Niemeier (102)

• & 🇩🇪 Angelique Kerber (31) → replaced by Kamilla Rakhimova (LL) † – not included on entry list & – withdrew from entry list