2022 Uruguay Open – Doubles

Rafael Matos and Felipe Meligeni Alves were the defending champions but only Meligeni Alves chose to defend his title, partnering Matheus Pucinelli de Almeida. They withdrew before their first round match.

Karol Drzewiecki and Piotr Matuszewski won the title after defeating Facundo Díaz Acosta and Luis David Martínez 6–4, 6–4 in the final.

Seeds
• # 🇦🇷 Guido Andreozzi / 🇦🇷 Guillermo Durán (semifinals)

• # 🇧🇴 Boris Arias / 🇧🇴 Federico Zeballos (first round)

• # 🇦🇷 Facundo Díaz Acosta / 🇻🇪 Luis David Martínez (final)

• # 🇵🇱 Karol Drzewiecki / 🇵🇱 Piotr Matuszewski (champions)