2022 Uruguay Open – Singles

Hugo Dellien was the defending champion but chose not to defend his title.

Genaro Alberto Olivieri won the title after defeating Tomás Martín Etcheverry 6–7(3–7), 7–6(7–5), 6–3 in the final.

Seeds
• # 🇦🇷 Federico Coria (withdrew)

• # 🇦🇷 Tomás Martín Etcheverry (final)

• # 🇩🇪 Daniel Altmaier (semifinals)

• # 🇦🇷 Facundo Bagnis (quarterfinals)

• # 🇮🇹 Marco Cecchinato (first round)

• # 🇦🇷 Camilo Ugo Carabelli (first round)

• # 🇦🇷 Juan Manuel Cerúndolo (second round, retired)

• # 🇮🇹 Franco Agamenone (semifinals)