2022 WTA Argentina Open – Singles

Anna Bondár was the reigning champion, but chose not to participate.

Third seed Panna Udvardy won the title, defeating Danka Kovinić in the final, 6–4, 6–1.

Seeds
• # 🇪🇬 Mayar Sherif (withdrew)

• # 🇲🇪 Danka Kovinić (final)

• # 🇭🇺 Panna Udvardy (champion)

• # 🇦🇹 Julia Grabher (first round)

• # Tamara Zidanšek (first round)

• # 🇮🇹 Sara Errani (quarterfinals)

• # 🇭🇺 Réka Luca Jani (first round)

• # 🇧🇷 Laura Pigossi (quarterfinals)

• # 🇰🇷 Jang Su-jeong (first round)

Seeds
• # Diana Shnaider (qualified)

• # 🇨🇿 Sára Bejlek (qualifying competition, lucky loser)

• # 🇹🇷 İpek Öz (qualifying competition, lucky loser)

• # 🇷🇸 Natalija Stevanović (qualified)

Qualifiers
• # Diana Shnaider

• # 🇦🇷 Julia Riera

• # 🇯🇵 Yuki Naito

• # 🇷🇸 Natalija Stevanović

Lucky losers
• # 🇨🇿 Sára Bejlek

• # Darya Astakhova

• # 🇹🇷 İpek Öz