2022 WTA Lyon Open – Singles

Zhang Shuai defeated wildcard Dayana Yastremska in the final, 3–6, 6–3, 6–4 to win the Singles title at the 2022 WTA Lyon Open. It was her first title since 2017. Yastremska was participating in her first event since fleeing her native country of Ukraine due to the 2022 Russian invasion of Ukraine.

Clara Tauson was the defending champion, but chose not to participate.

Seeds
• # 🇮🇹 Camila Giorgi (first round)

• # 🇷🇴 Sorana Cîrstea (semifinals)

• # Viktorija Golubic (second round)

• # 🇫🇷 Alizé Cornet (first round)

• # 🇮🇹 Jasmine Paolini (quarterfinals)

• # Ana Konjuh (first round)

• # 🇧🇪 Alison Van Uytvanck (quarterfinals)

• # 🇨🇳 Zhang Shuai (champion)

Seeds
• # Ekaterine Gorgodze (qualifying competition)

• # 🇯🇵 Mai Hontama (qualifying competition, lucky loser)

• # 🇬🇧 Katie Boulter (qualified)

• # 🇪🇸 Cristina Bucșa (qualified)

• # Lesley Pattinama Kerkhove (qualifying competition)

• # Anna Blinkova (first round, retired)

• # Ylena In-Albon (qualifying competition)

• # 🇦🇹 Julia Grabher (first round)

• # Stefanie Vögele (qualified)

• # 🇩🇪 Laura Siegemund (qualifying competition)

• # Anastasia Gasanova (first round)

• # Mariam Bolkvadze (qualified)

Qualifiers
• # Stefanie Vögele

• # Mariam Bolkvadze

• # 🇬🇧 Katie Boulter

• # 🇪🇸 Cristina Bucșa

• # 🇯🇵 Yuriko Miyazaki

• # 🇩🇪 Tamara Korpatsch

Lucky loser
• # 🇯🇵 Mai Hontama