2022 Western & Southern Open – Women's singles

Caroline Garcia defeated Petra Kvitová in the final, 6–2, 6–4 to win the women's singles tennis title at the 2022 Cincinnati Masters. It was her third WTA 1000 title, and her first since 2017. Garcia was the first qualifier to reach and to win the final of a WTA 1000 event.

Ashleigh Barty was the reigning champion, but retired from professional tennis in March 2022.

This was the penultimate professional tournament of 23-time major champion and former world No. 1 Serena Williams; she lost to Emma Raducanu in the first round.

Seeds
The top eight seeds received a bye into the second round. • 🇵🇱 Iga Świątek (third round)

• 🇪🇪 Anett Kontaveit (third round)

• 🇪🇸 Paula Badosa (second round)

• Maria Sakkari (second round)

• 🇹🇳 Ons Jabeur (third round)

•  Aryna Sabalenka (semifinals)

• 🇺🇸 Jessica Pegula (quarterfinals)

• 🇪🇸 Garbiñe Muguruza (second round)

•  Daria Kasatkina (first round)

• 🇬🇧 Emma Raducanu (third round)

• 🇺🇸 Coco Gauff (first round, retired)

•  Belinda Bencic (first round)

• 🇨🇦 Leylah Fernandez (first round)

• 🇨🇿 Karolína Plíšková (second round)

• 🇷🇴 Simona Halep (second round, withdrew)

•  Jeļena Ostapenko (second round)

Seeded players
The following are the seeded players. Seedings are based on WTA rankings as of August 8, 2022. Rank and points before are as of August 15, 2022.

The event is not mandatory on the women's side and points from the 2021 tournament are included in the table below only if they counted towards the player's ranking as of August 15, 2022. For other players, the points defending column shows the lower of (a) points from her second-highest non-mandatory WTA 1000 tournament (which are required to be counted in her ranking) or (b) her 16th best result.

Points defending will be replaced at the end of the tournament by (a) the player's points from the 2022 tournament, (b) her 17th best result, or (c) points from her second-highest non-mandatory WTA 1000 event.

† Points from the player's 16th best result (for points defending) or 17th best result (for points won), in each case as of August 15, 2022. ‡ Points from the player's second-best non-mandatory WTA 1000 event, which are required to be counted in her ranking. § The player is defending points from a WTA 125 tournament (Chicago).

Wild cards
• 🇺🇸 Sofia Kenin

• 🇺🇸 Caty McNally

• 🇺🇸 Shelby Rogers

• 🇺🇸 Sloane Stephens

• 🇺🇸 Venus Williams

Protected ranking
• 🇨🇦 Bianca Andreescu

• 🇨🇿 Karolína Muchová

• 🇺🇸 Serena Williams

Withdrawals
• 🇨🇦 Bianca Andreescu → replaced by 🇪🇸 Nuria Párrizas Díaz
 * Before the tournament

• 🇺🇸 Danielle Collins → replaced by Petra Martić

• 🇩🇪 Angelique Kerber → replaced by 🇪🇸 Sara Sorribes Tormo

• 🇨🇿 Karolína Muchová → replaced by  Anastasia Potapova

• 🇺🇸 Amanda Anisimova (right foot injury)
 * During the tournament

• 🇨🇿 Marie Bouzková (right trunk injury)

• 🇷🇴 Simona Halep (right thigh injury)

Retirements
• 🇺🇸 Coco Gauff (left ankle injury)

• Anna Kalinskaya (dizziness)

Seeds
• # 🇷🇴 Irina-Camelia Begu (first round)

• # 🇫🇷 Caroline Garcia (qualified)

• # 🇨🇿 Marie Bouzková (qualified)

• # Anastasia Potapova (qualifying competition, lucky loser)

• # Clara Tauson (first round)

• # 🇺🇦 Anhelina Kalinina (qualified)

• # 🇭🇺 Anna Bondár (first round)

• # 🇮🇹 Jasmine Paolini (first round)

• # 🇪🇸 Nuria Párrizas Díaz (qualifying competition, lucky loser)

• # Petra Martić (qualifying competition, lucky loser)

• # Varvara Gracheva (first round)

• # 🇨🇿 Kateřina Siniaková (first round)

• # Kaja Juvan (first round)

• # 🇨🇴 Camila Osorio (first round)

• # Anna Kalinskaya (qualified)

• # 🇵🇱 Magda Linette (qualifying competition)

Qualifiers
• # 🇨🇿 Tereza Martincová

• # 🇫🇷 Caroline Garcia

• # 🇨🇿 Marie Bouzková

• # Anna Kalinskaya

• # 🇦🇺 Ajla Tomljanović

• # 🇺🇦 Anhelina Kalinina

• # 🇺🇸 Taylor Townsend

• # 🇺🇦 Marta Kostyuk

Lucky losers
• # 🇪🇸 Nuria Párrizas Díaz

• # Petra Martić

• # Anastasia Potapova