2022 Winston-Salem Open

The 2022 Winston-Salem Open was a men's tennis tournament play on outdoor hard courts. It was the 53rd edition of the Winston-Salem Open (as successor to previous tournaments in New Haven and Long Island), and part of the ATP Tour 250 Series of the 2022 ATP Tour. It took place at Wake Forest University in Winston-Salem, North Carolina, United States, from August 21 through August 27, 2022. It was the last event on the 2022 US Open Series before the 2022 US Open.

Singles

 * 🇫🇷 Adrian Mannarino def. 🇷🇸 Laslo Đere, 7–6(7–1), 6–4

Doubles

 * 🇦🇺 Matthew Ebden / 🇬🇧 Jamie Murray def. Hugo Nys / 🇵🇱 Jan Zieliński, 6–4, 6–2

Prize money

 * per team

Seeds
† Rankings are as of 15 August 2022.

Other entrants
The following players received wildcard entry into the singles main draw:
 * 🇧🇬 Grigor Dimitrov
 * 🇦🇹 Dominic Thiem
 * 🇺🇸 J. J. Wolf
 * 🇸🇪 Mikael Ymer

The following players received entry using a protected ranking:
 * 🇬🇧 Kyle Edmund

The following players received entry from the qualifying draw:
 * Marc-Andrea Hüsler
 * 🇦🇺 Jason Kubler
 * 🇺🇸 Emilio Nava
 * 🇦🇺 Christopher O'Connell

The following players received entry as lucky losers:
 * 🇯🇵 Taro Daniel
 * 🇭🇺 Márton Fucsovics
 * Tallon Griekspoor
 * 🇯🇵 Shintaro Mochizuki
 * Michail Pervolarakis

Withdrawals

 * Before the tournament
 * 🇦🇷 Sebastián Báez → replaced by 🇭🇺 Márton Fucsovics
 * 🇰🇿 Alexander Bublik → replaced by 🇫🇷 Adrian Mannarino
 * 🇪🇸 Pablo Carreño Busta → replaced by 🇯🇵 Taro Daniel
 * 🇧🇴 Hugo Dellien → replaced by 🇯🇵 Shintaro Mochizuki
 * 🇦🇷 Tomás Martín Etcheverry → replaced by Michail Pervolarakis
 * 🇺🇸 Marcos Giron → replaced by 🇩🇪 Peter Gojowczyk
 * 🇫🇷 Quentin Halys → replaced by 🇺🇸 Denis Kudla
 * 🇸🇰 Alex Molčan → replaced by 🇦🇺 John Millman
 * 🇺🇸 Brandon Nakashima → replaced by 🇬🇧 Jack Draper
 * 🇩🇪 Oscar Otte → replaced by 🇫🇷 Richard Gasquet
 * 🇺🇸 Tommy Paul → replaced by 🇷🇸 Dušan Lajović
 * Holger Rune → replaced by Tallon Griekspoor
 * 🇺🇸 Frances Tiafoe → replaced by 🇺🇸 Steve Johnson

Seeds
† Rankings are as of 15 August 2022.

Other entrants
The following pairs received wildcard entry into the doubles main draw :
 * 🇺🇸 Robert Galloway / 🇺🇸 Alex Lawson
 * 🇹🇳 Skander Mansouri / 🇺🇸 Matthew Thomson

Withdrawals

 * Marcelo Arévalo / Jean-Julien Rojer → replaced by  Hugo Nys / 🇵🇱 Jan Zieliński
 * 🇦🇺 Matthew Ebden / 🇦🇺 Max Purcell → replaced by 🇦🇺 Matthew Ebden / 🇬🇧 Jamie Murray
 * 🇲🇽 Santiago González / 🇦🇷 Andrés Molteni → replaced by 🇰🇿 Aleksandr Nedovyesov / 🇵🇰 Aisam-ul-Haq Qureshi
 * Wesley Koolhof / 🇬🇧 Neal Skupski → replaced by 🇫🇷 Fabrice Martin / 🇬🇧 Jonny O'Mara
 * 🇩🇪 Kevin Krawietz / 🇩🇪 Andreas Mies → replaced by 🇧🇪 Sander Gillé / 🇧🇪 Joran Vliegen
 * 🇬🇧 Jamie Murray / 🇧🇷 Bruno Soares → replaced by 🇺🇸 Nathaniel Lammons / 🇺🇸 Jackson Withrow