2022 Winston-Salem Open – Singles

Adrian Mannarino defeated Laslo Đere in the final, 7–6(7–1), 6–4 to win the singles tennis title at the 2022 Winston-Salem Open. Mannarino saved four match points en route to the title, in his first-round match against Christopher O'Connell.

Ilya Ivashka was the defending champion, but lost in the third round to Marc-Andrea Hüsler.

Seeds
All seeds receive a bye into the second round. • 🇧🇬 Grigor Dimitrov (second round, retired)

• Botic van de Zandschulp (semifinals)

• Holger Rune (withdrew)

• 🇺🇸 Maxime Cressy (quarterfinals)

• 🇮🇹 Lorenzo Musetti (second round)

• Nikoloz Basilashvili (second round)

• 🇦🇷 Sebastián Báez (withdrew)

• 🇪🇸 Albert Ramos Viñolas (third round)

• 🇫🇮 Emil Ruusuvuori (second round)

• 🇫🇷 Benjamin Bonzi (quarterfinals)

• Ilya Ivashka (third round)

• 🇪🇸 Pedro Martínez (second round)

• 🇬🇧 Jack Draper (quarterfinals)

• 🇮🇹 Lorenzo Sonego (third round)

• 🇪🇸 Jaume Munar (third round)

• João Sousa (second round)

Seeds
• # Tallon Griekspoor (qualifying competition, lucky loser)

• # 🇭🇺 Márton Fucsovics (qualifying competition, lucky loser)

• # 🇯🇵 Taro Daniel (qualifying competition, lucky loser)

• # Marc-Andrea Hüsler (qualified)

• # 🇦🇺 Jason Kubler (qualified)

• # 🇦🇺 Christopher O'Connell (qualified)

• # 🇺🇸 Emilio Nava (qualified)

• # 🇯🇵 Shintaro Mochizuki (qualifying competition, lucky loser)

Qualifiers
• # 🇦🇺 Christopher O'Connell

• # 🇦🇺 Jason Kubler

• # 🇺🇸 Emilio Nava

• # Marc-Andrea Hüsler

Lucky losers
• # Tallon Griekspoor

• # 🇭🇺 Márton Fucsovics

• # 🇯🇵 Shintaro Mochizuki

• # 🇯🇵 Taro Daniel

• # Michail Pervolarakis