2022 Zagreb Ladies Open

The 2022 Zagreb Ladies Open was a professional tennis tournament played on outdoor clay courts. It was the twelfth edition of the tournament which was part of the 2022 ITF Women's World Tennis Tour. It took place in Zagreb, Croatia between 25 April and 1 May 2022.

Seeds

 * 1 Rankings are as of 18 April 2022.

Other entrants
The following players received wildcards into the singles main draw:
 * Lucija Ćirić Bagarić
 * Petra Marčinko
 * 🇷🇸 Lola Radivojević
 * Donna Vekić

The following players received entry from the qualifying draw:
 * Lea Bošković
 * Živa Falkner
 * Tena Lukas
 * 🇩🇪 Eva Lys
 * Ekaterina Makarova
 * Nina Potočnik
 * Antonia Ružić
 * Tara Würth

Singles

 * 🇩🇪 Jule Niemeier def. 🇭🇺 Réka Luca Jani, 6–2, 6–2

Doubles

 * 🇨🇿 Anastasia Dețiuc / 🇺🇦 Katarina Zavatska def. 🇲🇰 Lina Gjorcheska / Irina Khromacheva, 6–4, 6–7(5–7), [11–9].