2022 Zagreb Ladies Open – Singles

Anhelina Kalinina was the defending champion but chose not to participate.

Jule Niemeier won the title, defeating Réka Luca Jani in the final, 6–2, 6–2.

Seeds
• # Donna Vekić (first round)

• # 🇩🇪 Jule Niemeier (champion)

• # 🇭🇺 Réka Luca Jani (final)

• # 🇦🇷 Paula Ormaechea (second round)

• # Polona Hercog (first round)

• # Despina Papamichail (second round)

• # 🇩🇪 Anna-Lena Friedsam (first round, retired)

• # 🇨🇿 Linda Nosková (second round)