2022 Zagreb Open – Singles

Sebastián Báez was the defending champion but chose not to defend his title.

Filip Misolic won the title after defeating Mili Poljičak 6–3, 7–6(8–6) in the final.

Seeds
• # 🇦🇺 Jordan Thompson (first round)

• # 🇦🇺 Aleksandar Vukic (first round)

• # 🇦🇺 Christopher O'Connell (first round)

• # 🇧🇦 Damir Džumhur (withdrew)

• # 🇨🇿 Vít Kopřiva (second round)

• # 🇦🇺 Jason Kubler (semifinals)

• # 🇦🇷 Juan Pablo Ficovich (first round)

• # 🇮🇹 Federico Gaio (second round)