2023 Cali Open – Singles

Facundo Mena was the defending champion but chose not to defend his title.

Federico Delbonis won the title after defeating Guido Andreozzi 6–4, 6–7(6–8), 6–3 in the final.

Seeds
• # Alejandro Tabilo (quarterfinals)

• # 🇦🇷 Román Andrés Burruchaga (first round)

• # 🇨🇦 Alexis Galarneau (second round)

• # 🇨🇴 Nicolás Mejía (second round)

• # 🇦🇷 Santiago Rodríguez Taverna (semifinals)

• # 🇦🇷 Federico Delbonis (champion)

• # 🇧🇷 João Lucas Reis da Silva (first round)

• # 🇦🇷 Guido Andreozzi (final)