2023 Challenger Santa Fe – Singles

This was the first edition of the tournament.

Mariano Navone won the title after defeating Daniel Vallejo 6–2, 6–4 in the final.

Seeds
• # 🇦🇷 Mariano Navone (champion)

• # 🇦🇷 Santiago Rodríguez Taverna (first round)

• # 🇦🇷 Román Andrés Burruchaga (semifinals)

• # 🇦🇷 Francisco Comesaña (semifinals)

• # 🇧🇷 Gustavo Heide (first round)

• # 🇧🇷 Eduardo Ribeiro (first round)

• # 🇵🇪 Nicolás Álvarez (withdrew)

• # 🇧🇷 Pedro Boscardin Dias (quarterfinals)

• # 🇦🇷 Matías Franco Descotte (second round)