2023 Challenger Santa Fe II – Singles

Mariano Navone was the defending champion and successfully defended his title after defeating Andrea Pellegrino 3–6, 6–2, 6–3 in the final.

Seeds
• # 🇦🇷 Federico Coria (quarterfinals, retired)

• # 🇦🇷 Juan Manuel Cerúndolo (first round)

• # Tomás Barrios Vera (quarterfinals)

• # 🇨🇿 Vít Kopřiva (semifinals)

• # 🇦🇷 Francisco Comesaña (second round)

• # 🇬🇧 Jan Choinski (first round, retired)

• # 🇦🇷 Genaro Alberto Olivieri (first round, retired)

• # 🇧🇷 Felipe Meligeni Alves (second round)