2023 Challenger de Buenos Aires – Singles

Juan Manuel Cerúndolo was the defending champion but lost in the quarterfinals to Luciano Darderi.

Mariano Navone won the title after defeating Federico Coria 2–6, 6–3, 6–4 in the final.

Seeds
• # 🇦🇷 Federico Coria (final)

• # 🇦🇷 Juan Manuel Cerúndolo (quarterfinals)

• # 🇦🇷 Facundo Díaz Acosta (semifinals)

• # Tomás Barrios Vera (first round)

• # 🇨🇿 Vít Kopřiva (second round)

• # Alejandro Tabilo (first round)

• # 🇦🇷 Francisco Comesaña (quarterfinals)

• # 🇬🇧 Jan Choinski (quarterfinals)