2023 Challenger de Santiago – Singles

Hugo Dellien was the defending champion and successfully defended his title after defeating Thiago Seyboth Wild 3–6, 6–3, 6–3 in the final.

Seeds
• # Nicolás Jarry (withdrew)

• # 🇮🇹 Marco Cecchinato (first round)

• # 🇦🇷 Facundo Bagnis (quarterfinals)

• # 🇧🇴 Hugo Dellien (champion)

• # 🇦🇷 Juan Manuel Cerúndolo (first round)

• # 🇦🇷 Camilo Ugo Carabelli (second round)

• # 🇮🇹 Franco Agamenone (quarterfinals)

• # 🇦🇷 Facundo Díaz Acosta (semifinals)