2023 Florianópolis Challenger – Singles

Igor Marcondes was the defending champion but chose not to defend his title.

Tomás Barrios Vera won the title after defeating Alejandro Tabilo 6–4, 6–4 in the final.

Seeds
• # Tomás Barrios Vera (champion)

• # Alejandro Tabilo (final)

• # 🇮🇹 Luciano Darderi (first round)

• # 🇦🇷 Andrea Collarini (second round)

• # 🇦🇷 Genaro Alberto Olivieri (quarterfinals)

• # 🇧🇷 Thiago Seyboth Wild (second round)

• # 🇮🇹 Alessandro Giannessi (quarterfinals)

• # 🇦🇷 Francisco Comesaña (quarterfinals)