2023 Internazionali Femminili di Palermo – Singles

Zheng Qinwen defeated Jasmine Paolini in the final, 6–4, 1–6, 6–1 to win the singles tennis title at the 2023 Internazionali Femminili di Palermo. It was Zheng's first WTA Tour singles title, and she was the first Chinese player to win the singles title at Palermo.

Irina-Camelia Begu was the reigning champion, but she chose to compete at the WTA 125 event in Iași instead.

Seeds
• # Daria Kasatkina (quarterfinals)

• # 🇨🇳 Zheng Qinwen (champion)

• # 🇪🇬 Mayar Sherif (semifinals)

• # 🇮🇹 Elisabetta Cocciaretto (first round)

• # 🇮🇹 Jasmine Paolini (final)

• # 🇮🇹 Lucia Bronzetti (first round)

• # 🇺🇸 Emma Navarro (quarterfinals)

• # 🇦🇹 Julia Grabher (first round)

Seeds
• # 🇮🇹 Nuria Brancaccio (qualified)

• # 🇺🇦 Katarina Zavatska (first round)

• # 🇺🇸 Hailey Baptiste (first round)

• # Tatiana Prozorova (qualified)

• # 🇹🇷 Çağla Büyükakçay (first round)

• # 🇧🇮 Sada Nahimana (first round)

• # Suzan Lamens (first round)

• # 🇮🇹 Matilde Paoletti (withdrew)

• # Eva Vedder (qualified)

• # 🇲🇹 Francesca Curmi (qualifying competition, lucky loser)

• # Sofya Lansere (qualifying competition, lucky loser)

• # 🇮🇹 Martina Colmegna (qualifying competition)

Qualifiers
• # 🇮🇹 Nuria Brancaccio

• # 🇫🇷 Tessah Andrianjafitrimo

• # Eva Vedder

• # Tatiana Prozorova

• # 🇷🇸 Mia Ristić

• # 🇮🇹 Aurora Zantedeschi

Lucky losers
• # 🇲🇹 Francesca Curmi

• # Sofya Lansere