2023 Internazionali di Tennis Città di Vicenza – Singles

Andrea Pellegrino was the defending champion but chose not to defend his title.

Francisco Comesaña won the title after defeating Pablo Llamas Ruiz 3–6, 6–2, 6–2 in the final.

Seeds
• # 🇮🇹 Francesco Passaro (semifinals)

• # 🇮🇹 Luca Nardi (quarterfinals)

• # 🇨🇿 Vít Kopřiva (first round)

• # 🇮🇹 Riccardo Bonadio (first round)

• # 🇮🇹 Franco Agamenone (first round)

• # 🇮🇹 Mattia Bellucci (second round)

• # 🇧🇪 Kimmer Coppejans (first round)

• # 🇯🇵 Sho Shimabukuro (first round)