2023 Libéma Open – Women's singles

Defending champion Ekaterina Alexandrova defeated Veronika Kudermetova in the final, 4–6, 6–4, 7–6(7–3) to win the women's singles tennis title at the 2023 Libéma Open. Alexandrova lost just one set en route to the title, to Kudermetova in the final, ending a winning streak of 18 consecutive sets at the tournament. Alexandrova became the first player to defend the title at 's-Hertogenbosch since Tamarine Tanasugarn in 2009, and just the second player to defend the title overall. Furthermore, she became the first player to defend a WTA Tour grass court title since Petra Kvitová at the 2018 Birmingham Classic.

Seeds
• # Veronika Kudermetova (final)

• # Liudmila Samsonova (quarterfinals, retired)

• # Victoria Azarenka (second round)

• # Ekaterina Alexandrova (champion)

• #🇧🇪 Elise Mertens (withdrew)

• #🇨🇦 Bianca Andreescu (second round)

• # Aliaksandra Sasnovich (semifinals)

• #🇺🇸 Caty McNally (second round)

Seeds
• # 🇦🇺 Priscilla Hon (qualifying competition, lucky loser)

• # 🇺🇸 CoCo Vandeweghe (first round)

• # 🇺🇸 Sachia Vickery (qualifying competition, lucky loser)

• # 🇨🇦 Carol Zhao (qualified)

• # 🇺🇸 Emina Bektas (qualified)

• # 🇯🇵 Mai Hontama (qualifying competition)

• # 🇧🇪 Magali Kempen (first round)

• # Dalila Jakupović (first round)

• # 🇮🇳 Ankita Raina (qualifying competition)

• # 🇷🇸 Natalija Stevanović (qualified)

• # Kristina Dmitruk (qualifying competition)

• # 🇹🇷 Zeynep Sönmez (qualified)

Qualifiers
• # 🇷🇸 Natalija Stevanović

• # 🇩🇪 Lena Papadakis

• # 🇹🇷 Zeynep Sönmez

• # 🇨🇦 Carol Zhao

• # 🇺🇸 Emina Bektas

• # Susan Bandecchi

Lucky losers
• # 🇦🇺 Priscilla Hon

• # 🇺🇸 Sachia Vickery