2023 Monterrey Open – Singles

Donna Vekić defeated Caroline Garcia in the final, 6–4, 3–6, 7–5 to win the women's singles tennis title at the 2023 Monterrey Open. It was her fourth career WTA title.

Leylah Fernandez was the two-time defending champion, but chose not to participate this year.

Seeds
• #🇫🇷 Caroline Garcia (final)

• #🇨🇿 Marie Bouzková (first round)

• # Donna Vekić (champion)

• #🇧🇪 Elise Mertens (semifinals)

• #🇨🇳 Zhu Lin (semifinals)

• #🇨🇿 Kateřina Siniaková (first round)

• #🇪🇬 Mayar Sherif (quarterfinals)

• #🇮🇹 Elisabetta Cocciaretto (quarterfinals)

Seeds
• # Kamilla Rakhimova (qualified)

• # 🇺🇦 Lesia Tsurenko (qualified)

• # 🇧🇷 Laura Pigossi (first round)

• # Simona Waltert (first round)

• # 🇪🇸 Marina Bassols Ribera (qualifying competition, lucky loser)

• # 🇮🇹 Lucrezia Stefanini (first round)

• # 🇦🇺 Kimberly Birrell (qualifying competition)

• # 🇸🇪 Rebecca Peterson (special exempt to main draw)

• # Ana Konjuh (qualifying competition)

• # 🇪🇸 Aliona Bolsova (qualifying competition)

• # Despina Papamichail (qualified)

• # 🇺🇸 Katrina Scott (first round)

Qualifiers
• # Kamilla Rakhimova

• # 🇺🇦 Lesia Tsurenko

• # 🇺🇸 Caroline Dolehide

• # 🇷🇴 Elena-Gabriela Ruse

• # Despina Papamichail

• # 🇺🇸 Sachia Vickery

Lucky loser
• # 🇪🇸 Marina Bassols Ribera