2023 Open Città della Disfida – Singles

Nuno Borges was the defending champion but chose not to defend his title.

Shintaro Mochizuki won the title after defeating Santiago Rodríguez Taverna 6–1, 6–4 in the final.

Seeds
• # Alexander Shevchenko (first round)

• # 🇦🇹 Filip Misolic (first round)

• # 🇮🇹 Franco Agamenone (semifinals)

• # 🇫🇷 Benoît Paire (first round)

• # 🇮🇹 Francesco Maestrelli (first round)

• # 🇫🇷 Laurent Lokoli (quarterfinals)

• # 🇨🇿 Zdeněk Kolář (second round)

• # 🇮🇹 Flavio Cobolli (first round)