2023 San Luis Open Challenger – Women's singles

This was the first edition of the tournament as a part of the 2023 WTA 125 tournaments.

Elisabetta Cocciaretto won the title, defeating Sara Errani in the final, 5–7, 6–4, 7–5.

Seeds
• #🇮🇹 Elisabetta Cocciaretto (champion)

• #🇩🇪 Tatjana Maria (quarterfinals)

• #🇭🇺 Dalma Gálfi (second round)

• #🇺🇦 Kateryna Baindl (first round)

• # Kamilla Rakhimova (second round)

• #🇦🇹 Julia Grabher (first round)

• #🇮🇹 Sara Errani (final)

• #🇧🇷 Laura Pigossi (quarterfinals)

Seeds
• # 🇫🇷 Carole Monnet (first round)

• # 🇺🇸 Hailey Baptiste (qualified)

• # 🇺🇸 Whitney Osuigwe (qualified)

• # 🇨🇴 Yuliana Lizarazo (first round)

Qualifiers
• # 🇻🇪 Andrea Gámiz

• # 🇺🇸 Hailey Baptiste

• # 🇺🇸 Whitney Osuigwe

• # Conny Perrin