2023 Sanremo Challenger – Singles

Holger Rune was the defending champion but chose not to defend his title.

Luca Van Assche won the title after defeating Juan Pablo Varillas 6–1, 6–3 in the final.

Seeds
• # 🇵🇪 Juan Pablo Varillas (final)

• # 🇮🇹 Marco Cecchinato (first round)

• # Alexander Shevchenko (second round)

• # Aslan Karatsev (first round)

• # 🇫🇷 Luca Van Assche (champion)

• # 🇮🇹 Matteo Arnaldi (first round)

• # Pavel Kotov (first round, retired)

• # 🇮🇹 Giulio Zeppieri (second round)