2023 Santa Cruz Challenger – Singles

Paul Jubb was the defending champion but chose not to defend his title.

Mariano Navone won the title after defeating Francisco Comesaña 4–6, 7–5, 6–1 in the final.

Seeds
• # 🇦🇷 Juan Manuel Cerúndolo (semifinals, retired)

• # 🇦🇷 Genaro Alberto Olivieri (quarterfinals)

• # 🇧🇴 Hugo Dellien (first round)

• # 🇦🇷 Thiago Agustín Tirante (quarterfinals, retired)

• # 🇦🇷 Francisco Comesaña (final)

• # 🇦🇷 Mariano Navone (champion)

• # 🇮🇹 Luciano Darderi (first round)

• # 🇦🇷 Camilo Ugo Carabelli (second round)