2023 US Open – Wheelchair women's singles

Five-time defending champion Diede de Groot defeated Yui Kamiji in the final, 6–2, 6–2 to win the women's singles wheelchair tennis title at the 2023 US Open. With the win, de Groot completed the Grand Slam for a third consecutive year, and won a twelfth consecutive major singles title (an all-time record in any tennis discipline). This marked the seventh consecutive year where de Groot and Kamiji contested the final.

Seeds
• # Diede de Groot (champion)

• #🇯🇵 Yui Kamiji (final)

• # Jiske Griffioen (semifinals, retired)

• #🇯🇵 Momoko Ohtani (semifinals)