2023 Uruguay Open – Singles

Genaro Alberto Olivieri was the defending champion but chose not to defend his title.

Facundo Díaz Acosta won the title after Thiago Monteiro retired trailing 3–6, 3–4 in the final.

Seeds
• # 🇦🇷 Pedro Cachin (first round)

• # 🇦🇷 Federico Coria (first round)

• # Tomás Barrios Vera (quarterfinals)

• # 🇦🇷 Facundo Díaz Acosta (champion)

• # Alejandro Tabilo (first round)

• # 🇧🇴 Hugo Dellien (semifinals)

• # 🇦🇷 Thiago Agustín Tirante (first round)

• # 🇦🇷 Francisco Comesaña (first round, retired)