2024–25 Leyton Orient F.C. season

The 2024–25 season is the 126th season in the history of Leyton Orient Football Club and their second consecutive season in League One. The club are participating in League One, the FA Cup, the EFL Cup, and the EFL Trophy.

Pre-season and friendlies
On 12 May, The O's announced they would return to Spain for a pre-season training camp in Málaga. Five days later, they announced they would travel to Hornchurch to kick-off the pre-season campaign. A second friendly, versus Dagenham & Redbridge was also shortly added. On June 4, the club added a double-header to their pre-season schedule, versus Welling United and St Albans City. Two weeks later, a fifth fixture was added, against Cheshunt. On 28 June, fixtures against Heart of Midlothian and Juventud de Torremolinos were added. A fixture to honour Justin Edinburgh against Tottenham Hotspur U21 was also later added.

Matches
On 26 June, the League One fixtures were announced.

EFL Cup
On 27 June, the draw for the first round was made, with Leyton Orient being drawn at home against Newport County.

EFL Trophy
In the group stage, Colchester were drawn into Southern Group E alongside Colchester United, Milton Keynes Dons and Arsenal U21.

Appearances and goals
List includes all first team players and any other matchday squad players

! colspan=14 style=background:#dcdcdc; text-align:center| Goalkeepers

! colspan=14 style=background:#dcdcdc; text-align:center| Defenders

! colspan=14 style=background:#dcdcdc; text-align:center| Midfielders

! colspan=14 style=background:#dcdcdc; text-align:center| Forwards


 * colspan="14"|Players away on loan:
 * colspan="14"|Players away on loan:


 * }