2024 Challenger Santa Fe – Singles

Mariano Navone was the defending champion but chose not to defend his title.

Andrea Collarini won the title after defeating Facundo Mena 6–2, 6–3 in the final.

Seeds
• # 🇧🇴 Hugo Dellien (second round, retired)

• # 🇧🇴 Murkel Dellien (first round)

• # 🇦🇷 Santiago Rodríguez Taverna (first round)

• # Hady Habib (first round)

• # 🇵🇪 Gonzalo Bueno (second round)

• # 🇪🇨 Álvaro Guillén Meza (first round)

• # 🇦🇷 Andrea Collarini (champion)

• # 🇧🇷 Pedro Sakamoto (first round)