2024 Challenger de Santiago – Singles

Hugo Dellien was the defending champion but lost in the quarterfinals to Facundo Bagnis.

Juan Pablo Varillas won the title after defeating Bagnis 6–3, 6–2 in the final.

Seeds
• # Tomás Barrios Vera (first round)

• # 🇵🇪 Juan Pablo Varillas (champion)

• # 🇦🇷 Camilo Ugo Carabelli (quarterfinals)

• # 🇦🇷 Facundo Bagnis (final)

• # 🇦🇷 Román Andrés Burruchaga (first round)

• # 🇦🇷 Juan Manuel Cerúndolo (second round)

• # 🇧🇴 Hugo Dellien (quarterfinals)

• # 🇦🇷 Genaro Alberto Olivieri (second round)