2024 San Luis Open Challenger – Men's singles

Tomás Barrios Vera was the defending champion but lost in the quarterfinals to Matías Soto.

Nicolás Mejía won the title after defeating Soto 6–1, 5–7, 6–2 in the final.

Seeds
• # 🇦🇷 Thiago Agustín Tirante (quarterfinals)

• # 🇦🇺 James Duckworth (second round)

• # Tomás Barrios Vera (quarterfinals)

• # Valentin Vacherot (first round)

• # 🇺🇸 Denis Kudla (semifinals)

• # 🇫🇷 Giovanni Mpetshi Perricard (semifinals)

• # 🇦🇺 Marc Polmans (first round)

• # 🇬🇧 Oliver Crawford (second round)