2024 San Luis Open Challenger – Women's singles

Elisabetta Cocciaretto was the defending champion, but lost in the semifinals to Nadia Podoroska.

Podoroska won the title after defeating Francesca Jones 6–1, 6–2 in the final.

Seeds
• #🇩🇪 Tatjana Maria (first round)

• #🇮🇹 Elisabetta Cocciaretto (semifinals)

• #🇪🇸 Sara Sorribes Tormo (first round)

• #🇦🇷 Nadia Podoroska (champion)

• # Erika Andreeva (second round, retired)

• #🇺🇸 Hailey Baptiste (second round)

• #🇫🇷 Alizé Cornet (first round, retired)

• #🇦🇷 María Lourdes Carlé (first round)

Seeds
• # 🇺🇦 Katarina Zavatska (qualifying competition)

• # 🇨🇦 Carol Zhao (qualifying competition)

• # 🇫🇷 Harmony Tan (qualifying competition)

• # 🇨🇳 You Xiaodi (qualified)

Qualifiers
• # 🇷🇴 Anca Todoni

• # 🇲🇽 Jéssica Hinojosa Gómez

• # 🇮🇹 Nuria Brancaccio

• # 🇨🇳 You Xiaodi