2024 Santa Cruz Challenger – Singles

Mariano Navone was the defending champion but chose not to defend his title.

Camilo Ugo Carabelli won the title after defeating Murkel Dellien 6–4, 6–2 in the final.

Seeds
• # 🇧🇷 Thiago Monteiro (semifinals)

• # 🇦🇷 Francisco Comesaña (second round, withdrew)

• # 🇦🇷 Camilo Ugo Carabelli (champion)

• # 🇧🇴 Hugo Dellien (first round)

• # 🇦🇷 Román Andrés Burruchaga (quarterfinals)

• # 🇦🇷 Juan Manuel Cerúndolo (quarterfinals)

• # 🇦🇷 Genaro Alberto Olivieri (second round)

• # 🇮🇹 Marco Cecchinato (first round)