2024 Santa Cruz Challenger II – Singles

Camilo Ugo Carabelli was the defending champion but chose not to defend his title.

Juan Manuel Cerúndolo won the title after defeating Álvaro Guillén Meza 3–6, 6–1, 6–4 in the final.

Seeds
• # 🇦🇷 Juan Manuel Cerúndolo (champion)

• # 🇧🇴 Murkel Dellien (second round)

• # 🇦🇷 Andrea Collarini (second round, retired)

• # Hady Habib (semifinals)

• # 🇪🇨 Álvaro Guillén Meza (final)

• # 🇧🇷 Pedro Sakamoto (quarterfinals)

• # 🇦🇷 Renzo Olivo (second round)

• # 🇦🇷 Facundo Mena (semifinals)