221 (disambiguation)

221 may refer to:

In time:
 * The year:
 * 221 AD
 * 221 BC

In mathematics:


 * 221 (number)

In geography:
 * Roads:
 * U.S. Route 221 in Virginia

In astronomy:
 * 221 Eos, a main-belt asteroid

In transportation:
 * Aircraft:
 * The Boeing 221 mail plane
 * Rail:
 * 221 series, a type of train in Japan

In weapons:
 * Firearms:
 * The .221 Remington Fireball pistol cartridge

In fiction:
 * 221B Baker Street, the address of Sherlock Holmes
 * Experiment 221, the codename for Sparky, a fictional alien character in the Lilo & Stitch franchise