23S rRNA (guanine2535-N1)-methyltransferase

23S rRNA (guanine2535-N1)-methyltransferase (, AviRa) is an enzyme with systematic name S-adenosyl-L-methionine:23S rRNA (guanine2535-N1)-methyltransferase. This enzyme catalyses the following chemical reaction


 * S-adenosyl-L-methionine + guanine2535 in 23S rRNA $$\rightleftharpoons$$ S-adenosyl-L-homocysteine + N1-methylguanine2535 in 23S rRNA

This is one of the methyltransferases from Streptomyces viridochromogenes. Streptomyces viridochromogenes produces the antibiotic avilamycin A which binds to the 50S ribosomal subunit to inhibit protein synthesis.