2C2-NBOMe

2C2-NBOMe (NBOMe-MMDPEA-2) is a phenethylamine derivative from the 25-NB class. It acts as a potent agonist at the 5-HT2A receptor with weaker activity at 5-HT2B and 5-HT2C, and produces a head-twitch response in animal studies which often correlates with potential for psychedelic effects in humans. It is related in structure to psychedelic amphetamine derivatives such as MMDA-2 and is the first phenethylamine derivative with a methylenedioxy substitution on the phenyl ring but no alkyl substitution on the alpha carbon, that has been shown to produce psychedelic-appropriate responding in animals.